SS-31 vs MOTS-c
Two mitochondrial research peptides that work at different levels.
SS-31 and MOTS-c are both studied in mitochondrial research, but they operate differently — SS-31 targets the inner membrane, while MOTS-c is a mitochondrial-DNA-encoded signaling peptide.
Side-by-side
| Attribute | SS-31 | MOTS-c |
|---|---|---|
| Type | Mitochondria-targeted peptide | Mitochondrial-derived peptide (mtDNA-encoded) |
| Studied mechanism | Binds cardiolipin at the inner membrane | AMPK and metabolic signaling |
| Research focus | Mitochondrial bioenergetics, oxidative stress | Glucose metabolism, exercise physiology |
| Form | Lyophilized powder | Lyophilized powder |
| Often studied together | Yes — complementary mitochondrial tools | Yes — complementary mitochondrial tools |
Which does the research favor?
They complement rather than compete — SS-31 for membrane-level bioenergetics, MOTS-c for metabolic signaling. Many mitochondrial protocols study both.
Explore both compounds
Each ships with its Certificate of Analysis. Compare, then choose the compound that fits your research question.
Full research pages
For research use only. These products are intended solely for in-vitro laboratory research and are not for human or veterinary use. Nothing here is medical advice or a therapeutic claim.